San Luis Vacations from $270

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

The Latest San Luis vacation packages

Price found within the past 48 hours. Click for updated prices.
QUINTA MARIA ISABEL

QUINTA MARIA ISABEL

$270
per person
Oct 22 - Oct 25
found 1 day ago
Roundtrip non-stop flight included
Guayaquil (GYE) to Cuenca (CUE)
10/10 Exceptional! (1 review)
Killary Lodge

Killary Lodge

$345
per person
Oct 22 - Oct 25
found 1 day ago
Roundtrip non-stop flight included
Guayaquil (GYE) to Cuenca (CUE)
9.8/10 Exceptional! (7 reviews)
A nice quiet getaway about 35 minutes from Cuenca. Surrounded by nature, enabling one to go for walks. It is a family run place and the hosts are very friendly and helpful.

Reviewed on Mar 5, 2026

Saya Hotel & Suites

Saya Hotel & Suites

$289
per person
Oct 22 - Oct 25
found 1 day ago
Roundtrip non-stop flight included
Guayaquil (GYE) to Cuenca (CUE)
No reviews
Estancia San Juan

Estancia San Juan

$353
per person
Oct 22 - Oct 25
found 1 day ago
Roundtrip non-stop flight included
Guayaquil (GYE) to Cuenca (CUE)
8.6/10 Excellent! (26 reviews)
Close to national park

Reviewed on Sep 14, 2026

Departamento de Lujo

Departamento de Lujo

$287
per person
Oct 31 - Nov 2
found 1 day ago
Roundtrip flight included
Quito (UIO) to Cuenca (CUE)
10/10 Exceptional! (1 review)
This apartment was very nice inside , it has all the appliances that you need, the only thing i didn't like is that the power was off several times due to the lack of rain, and the apartment was a little cold for my taste.

Reviewed on Oct 13, 2024

Don't see what you're looking for?
See all available trips from Columbus to San Luis
View all trips

San Luis Hotel Deals

Four Points By Sheraton Cuenca

Four Points By Sheraton Cuenca

Ave. Circunvalación Sur y Ave. Felipe II Cuenca
Fully refundableReserve now, pay when you stay
$109 nightly
$120 total
Sep 20 - Sep 21
9/10 Wonderful! (513 reviews)
"Mala comunicación ,cobrando un impuesto usando una terminologia inapropiada por parte del personal del hotel no es la constitucion es por una norma del SRI e igual el cobro es inapropiada ya que habla de una devolucion pero dicha devolucion no se podría ejecutar sin pagar dicho impuesto el me habla ..."

Reviewed on Sep 16, 2026

Four Points By Sheraton Cuenca
Vaway Hotel

Vaway Hotel

Padre Aguirre 8-17 y Mariscal Sucre Cuenca Azuay
Fully refundableReserve now, pay when you stay
$51 nightly
$51 total
Oct 19 - Oct 20
Vaway Hotel
Oro Verde Cuenca

Oro Verde Cuenca

Av Ordóñez Lasso S/N Cuenca Azuay
Fully refundableReserve now, pay when you stay
$109 nightly
$120 total
Sep 20 - Sep 21
9.4/10 Exceptional! (643 reviews)
"El desayuno muy bueno , el staff también perfecto ,vale la pena estar ahi x la Outdoor pool y el sauna turco , el sauna en seco quema demasiado se deveria regular para poder estar ahi xq quema demasiado y arde la cara ."

Reviewed on Sep 18, 2026

Oro Verde Cuenca
See all 438 properties in San Luis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best San Luis Vacation Packages

San Luis Essential Information

Language
Spanish
Currency
U.S dollars
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Mariscal Lamar Airport (CUE)

More vacations you might like

Frequently asked questions

How much does a San Luis vacation package cost?
Offering great value package deals from $270 on Expedia, you'll be pleasantly surprised at how much a vacation to San Luis costs! Expedia's packages mean less travel planning for you and greater savings.
What are the cheapest months to go to San Luis?
You can usually find lower prices and greater availability in January, June and December. Explore our cheap San Luis vacation packages and you could score some great off-season deals.
How many days is enough for San Luis?
The ideal length for your San Luis vacation depends on what you'd like to see. Typically, a few days to a week will give you enough time to hit all the major attractions and explore some hidden treasures along the way.
How to find the best San Luis package deals?
Bagging a cheap San Luis package deal is a breeze with Expedia. Once you've entered your trip dates and destination under our "Packages" tab, set your maximum budget, add a couple of filters and browse what's available. You can personalize your search by "Area," "Amenities," "Property type" and more. Sort the results by "Price: low to high" to view the most wallet-friendly San Luis package deals. Want a simple trick to get the biggest savings? Have some flexibility with your departure dates and consider going away on a weekday, when prices are usually lower.
Is it cheaper to book a San Luis vacation as a package?
An Expedia vacation package could land you great savings when compared to arranging flights and stays separately. Better still, you can tailor your San Luis escape to fit your exact needs. Choose your preferred flight time, select the hotel type and add a car rental. Browse our bundle deals and find out how much you can save.
When to book a vacation package to San Luis?
If you've got your San Luis travel dates confirmed, book as early as you can to grab some outstanding deals. With Expedia, you can often reserve some flights up to one year in advance. Prefer spontaneous trips? Our last-minute deals are ideal for impromptu escapes.
Does Expedia offer Book Now, Pay Later San Luis vacation packages?
Your San Luis trip should be a relaxing escape from your busy life, not a reason for money worries. So to allow you extra flexibility, we've teamed up with online lender Affirm to bring you our Book Now, Pay Later vacations. Pick one of our vacation packages with payment plans and spread the total cost over 3, 6 or 12 months. Plus, there aren't any hidden or late payment fees to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.